Kavox Labs operates a hypothesis-generation platform with a proprietary validation loop—ranking disease-associated genes for Alzheimer's and Parkinson's and falsifying candidate hypotheses in human organoid systems.
A three-stage gated pipeline engineering pre-registered zero-shot benchmarks, transparent evidence prioritization, and physical organoid feedback.
Strict pre-registered zero-shot evaluation protocols on OptimusKG incorporating degree-bias null controls, temporal edge splits, and absolute exclusion of LLM-based link prediction.
BioPathNet relational path models executing disease-associated gene recovery for Alzheimer's and Parkinson's across human genetics, autophagy soft priors, and direction-of-effect.
Physical wet-lab testing loop in CellCircuit patient-derived iPSC cortical and midbrain organoids, streaming empirical readouts directly into an immutable ledger.
Decoupling baseline reproduction, novel computational triage on OptimusKG, and permissive commercial asset creation.
Primary computational triage engine and host of the first link-prediction benchmark on OptimusKG.
Track-D serves as the core discovery engine for disease-associated gene recovery. It hosts SINA's prospective temporal evaluation splits, degree-stratified null evaluations, and candidate ranking.
Eliminating publication bias by cryptographically logging all outcomes—positive, negative, toxic, and inconclusive—into a WORM/object-lock protected audit trail.
Conventional research discards negative or inconclusive biological results, creating severely biased models. By hash-chaining every organoid readout into an immutable ledger, SINA continuously refines its computational prioritization model.
Translating computational candidate prioritization into empirical ground truth using patient-derived iPSC brain organoids.
Human cortical and midbrain organoids representing patient-specific CNS cell architecture for Alzheimer's and Parkinson's models.
Tier 1 autophagy-flux and cellular viability screens followed by Tier 2 high-throughput pheno-multiomics and target engagement assays.
All outcome polarities are hash-chained into the M7 Evidence Ledger, updating relational graph message-passing slots.